Esophageal Cancer Therapeutics Market - Epidemiology Analysis, Therapy, Development, Growth and Demand Forecast to 2024

Global esophageal cancer therapeutics market is expected to witness significant growth with an increasing awareness regarding cancer treatment and technological advancements. Also, high demand for safe and effective medications and rising prevalence of cancer are driving the growth of the global market. The regulatory bodies such as USFDA, EMA are supporting the growth of the global market by providing funding, designations and grants for speeding up the drug development process.

Esophageal cancer involves formation of malignant cells in the tissues of the esophagus. Esophagus is a muscular tube that enable food and liquids to move from the throat to the stomach. The main types of esophageal cancer are adenocarcinoma and squamous cell carcinoma. Adenocarcinoma forms in cells that produce and release mucus and other fluids. Squamous cell carcinoma forms in flat cells lining the esophagus. Esophageal squamous cell carcinoma includes heavy alcohol consumption and smoking as major risk factors, with gastroesophageal reflux disease and Barrett esophagus further contributing as the risk factors of esophageal adenocarcinoma. Esophageal cancer has no early signs or symptoms; therefore, an advanced stage diagnosis is difficult.

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Some of the major drivers for the global esophageal cancer therapeutics market include combination therapies, treatment advancements, increasing number of regulatory approvals for esophageal cancer and a rise in the number of cancer treatment centers. Moreover, the launch of new drug therapies for esophageal cancer is expected to contribute as a key market driver in the near future. Also with a dense pipeline, many new drug candidates are expected to enter the global esophageal cancer therapeutics market. Safety concerns and efficacy of the treatment are the major factors that can hinder the market growth over the forecast period. Other factors hampering the market growth include low availability of drugs commercially and high cost of therapy for the treatment of esophageal cancer.

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Certain chemotherapy medications such as Doxorubicin, Bleomycin, Vinblastine, Dacarbazine, Chlorambucil, Procarbazine Prednisolone, Mustine, Vincristine, Etoposide, Cyclophosphamide, Gemcitabine, Cisplatin and Cytarabine are well established as a conventional method. Immunotherapy, combination therapy, monoclonal antibodies and steroids have also been showing good results for the treatment of esophageal cancer.

Some of the key players operating in the global esophageal cancer therapeutics market include Genentech, Inc., Sanofi-Aventis, Eli Lilly and Company, Ono Pharmaceutical Co., Ltd., Merck & Co., Inc., Johnson & Johnson Pharmaceutical Research & Development, LLC, Gilead Sciences, and Bristol-Myers Squibb, among others.

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Oropharyngeal Cancer Therapeutics Market Segmental Analysis by Therapeutics, Diagnostics, Patient, Drugs Policy and Regulatory Landscape

The global oropharyngeal cancer therapeutics market is expected to have significant growth since the pipeline for oropharyngeal cancer is growing rapidly.

Also, there are no specific drugs available for the treatment of oropharyngeal cancer providing increased opportunities for the major key players.

Oral cavity tumor or oral tumor, is tumor that begins in the mouth (also known as the oral cavity). Oropharyngeal malignancy begins in the oropharynx, which is the part of the throat behind the mouth. The oral cavity comprises of lips, the inside lining of the lips and cheeks (buccal mucosa), the teeth, the gums, the front two-thirds of the tongue, the floor of the mouth below the tongue and the bony roof of the mouth (hard palate). The area behind the wisdom teeth, called the retromolar trigone is also sometimes included in the oral cavity, though it is often considered part of the oropharynx.

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The oropharynx is the part of the throat just behind the mouth and begins where the oral cavity stops. It comprises of base of the tongue (the back third of the tongue), the soft palate (the back part of the roof of the mouth), the tonsils, and the side and back wall of the throat.

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The oropharyngeal cancer therapeutics market is segmented based on the therapy which includes surgery, chemotherapy, radiation therapy, targeted therapy and palliative treatment. Chemotherapy holds the largest share since it contains maximum number of drugs including, Cisplatin, Carboplatin, 5-fluorouracil (5-FU), Paclitaxel (Taxol) and Docetaxel (Taxotere). The palliative treatment segment holds the second largest share including, ibuprofen, acetaminophen, morphine or similar drugs. Targeted therapy holds the lowest share and includes only one drug, Cetuximab which may be combined with radiation therapy.

Some of the key players operating in the oropharyngeal cancer therapeutics market include Genticel S.A., AstraZeneca Plc, Kolltan Pharmaceuticals Inc., PNP Therapeutics Inc., Novartis AG, Advaxis Inc., Merck & Co. Inc., VLPbio and Synta Pharmaceuticals Corp.

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Influenza Vaccine Market by Therapeutics, Diagnostics, Patient, Drugs Policy and Regulatory Landscape

The global influenza vaccine market is growing significantly due increasing awareness about the pandemic influenza viruses and increasing government involvement for vaccination against influenza viruses.Massive unexplored influenza vaccine marketin the emerging economiesare creating ample opportunities for the global influenza vaccine marketto grow at a significant rate in the forecasted period.The advanced research and development facilities and new vaccine developments by the companies are propelling the demand for safe and efficacious influenza vaccine. Influenza (flu) is a respiratory disease caused by mainly two types of influenza viruses namely, influenza A and B viruses. Influenza A viruses are of two types based on the proteins on the surface of virus: hemagglutinin (H) and neuraminidase (N).

In global influenza vaccine industry, there is a trend of development of intranasal vaccine due to the ease of self administration. According to Centers for Disease Control and Prevention (CDC),in 2009, approximately 151,700 to 575,400 people died due to H1N1 influenza pandemic or swine flu across the globe. In addition, the organization also reported that most deaths due to 2009 flu pandemic occurred in Africa and Southeast Asia region. Several vaccines have been developed to prevent pandemic and seasonal influenza viruses using recombinant DNA technology and extensive researches are going on to develop efficient influenza vaccines using cell culture technology. Various governmental and non-governmental organizations have been actively involved in promoting and monitoring vaccination programs aimed at immunising people against seasonal influenza viruses. This in turn fuels the growth of global influenza vaccine market.

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 Some of the factors driving the growth of the global influenza vaccine market are increasing research and development activities,increasing investment by companies for the development of influenza vaccine, technological advancements in recombinant DNA technology, large number of population with no immunization against influenza viruses in emerging economies,increasing healthcare expenditure, and increasing involvement of government and non-government organizations.In addition, geriatric population and people suffering from chronic diseases are at higher risk of developing influenza virus infection; hence, aging population and increasing prevalence of chronic diseases are also driving the demand of influenza vaccine market. However, stringent regulatory framework and low accessibility to remote areas aresome of the factors restraining the growth of the global influenza vaccine market to some extent.

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Geographically, North America will be leading the global influenza vaccine market in the coming years, due to high awareness of influenza viruses, high healthcare expenditure, and increasing research and development activities.In addition, the U.S. Food and Drug Administration (FDA), recommends vaccination as the most effective method to prevent influenza; hence, fueling the growth of influenza vaccine market in NorthAmerica region. Asia-Pacificis the fastest growing region in the global influenza vaccinemarket. The major reasons for the fastest growth in the region are massive unexplored market (as large number of people donot have access to vaccination), increasing involvement of government, and increasing healthcare expenditure.

Some of the major players operating in the global influenza vaccine market are GlaxoSmithKline,Sanofi Pasteur, Inc., ID Biomedical Corporation, CSL Limited, Novartis, Protein Sciences Corporaton, MedImmune, LLC, Sinovac Biotech, Serum Institute of India, and Hualun Biologicalsamong others.

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Infectious Disease Treatment Market Outlook - Top Companies, Trends and Future Prospects Details for Business Development

Infectious diseases are medical conditions or disorders caused by microorganisms such as bacteria, fungi, viruses and other parasites. Several organisms are present in and on human bodies. Some organisms are normally harmless and even helpful. However, under certain circumstances, some organisms cause diseases. Infectious diseases spread from one person to another. Moreover, some are transmitted by bites from insects and animals. Infectious diseases also occur by consumption of contaminated food and water.

Signs and symptoms of infectious diseases depend on the type of organism and infection. Some of the most common symptoms of infectious diseases include fatigue and fever. Mild complaints of infectious diseases treated from rest and home remedies, while some life-threatening infections require hospitalization. Infectious diseases, such chickenpox and measles are prevented by vaccination. Frequent and thorough hand-washing also protect human body from infectious diseases.

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North America dominates the global infectious disease treatment market followed by Europe. The U.S., followed by Canada, is the largest market for infectious disease treatment in the North American region. Key driving factor for infectious disease treatment market in the region is increasing research activities on various types of diseases. Germany, France and the U.K. are some of the largest markets for infectious diseases in Europe. However, Asia-Pacific represents the fastest growing region in the global infectious disease treatment market. This is due to minimal wages and availability of skilled professionals in the region. These factors attract drug manufacturing companies to invest in the Asian countries. In addition, in developing countries, such as China and India, government has launched several programs and initiatives to increase awareness about infectious diseases. China, Japan and India are largest infectious disease treatment markets in the region.

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Increasing prevalence of the infectious diseases is key driving factor for the global infectious disease treatment market. Increasing awareness and extensive R&D drugs pipelines are also enhancing the growth of global infectious disease market. Moreover, introduction of novel drugs, such as direct-acting antivirals, boosts the growth of global infectious disease treatment market.

However, patent expiry of various major drugs and presence of generic drugs are key restraint of the global infectious disease treatment market. Stringent regulations and legislations and side-effects of anti-infective drugs also hinder the growth of global infectious disease treatment market. Rapid product launches and increasing mergers and acquisitions between drug manufactures are emerging trends of the global infectious disease treatment market.

Some of the major competitors in the global infectious disease treatment market are F. Hoffmann-La Roche, GlaxoSmithKline, Merck, Johnson & Johnson, Pfizer, Gilead Sciences,  Bristol-Myers Squibb Company, AstraZeneca, Bayer AG, Novartis, Sanofi, AbbVie and Auritec Pharmaceuticals.

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Cytomegalovirus Retinitis Market Comprehensive Review of its Applications Growth Opportunities and Future Prospects

One of the major trends noticed in the cytomegalovirus retinitis market is usage of off-label drugs for the treatment of cytomegalovirus retinitis. Innovation of products focusing on better efficacy, growing demographics and growing economies in the developing countries, such as China and India, are some of the opportunities for global cytomegalovirus retinitis market.

Cytomegalovirus retinitis is eye disease caused due to retina inflammation of eye. The causative agent of the disease is cytomegalovirus, a herpes virus that affects the photosensitive cells of retina. After affecting the retina, the disease spreads from one eye to another eye, which can lead to blindness, if left untreated. Photophobia, blurred vision, seeing floaters and blind spots are the symptoms of cytomegalovirus retinitis. Cytomegalovirus retinitis usually affects people with weak immune system, including HIV affected patients. Various forms of cytomegalovirus retinitis medication are solutions, capsules, tablets and implants.

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Some of the major factors restraining the growth of the global cytomegalovirus retinitis market are lack of awareness among people for different types of eye diseases, rising healthcare cost in developing countries and lack of healthcare insurance. Majority of the population do not have proper access to primary healthcare services because of poverty and absence of health insurance, which is also hindering the growth of cytomegalovirus retinitis market. The other major challenge for the global cytomegalovirus retinitis market is lack of approved treatment guidelines by the World Health Organization (WHO).

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North America has the largest market for cytomegalovirus retinitis due to improved medical facilities and increasing occurrence of cytomegalovirus retinitis cases in the region. Asia-Pacific is growing with the highest rate among global cytomegalovirus retinitis market. In Asia-Pacific, China and India are the two fastest growing cytomegalovirus retinitis markets, attributed to raising government initiatives and support and large population in these countries.

Some of the major competitors of global cytomegalovirus retinitis market are, Shire Plc, F. Hoffmann-La Roche AG, Hospira Inc., Chimerix Inc., Gilead Sciences Inc., pSivida, Auritec Pharmaceuticals Inc., Sanofi S.A., and Isis Pharmaceuticals Inc.

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Chronic Lymphocytic Leukemia (CLL) Therapeutics Market Analysis by Stages, Drug Class, Company Profile, Phase of Development, and Discovery Stage Insights

The global chronic lymphocytic leukemia therapeutics market is expected to create more opportunities in oncology due to promising pipeline and positive clinical data of drug candidates. The existing drugs for the treatment of chronic lymphocytic leukemia is the be most effective treatment. The American Cancer Society, and other regulatory bodies are supporting the chronic lymphocytic leukemia therapeutics market by providing funding and grants. The market is being driven by different factors such as rising awareness for the cancer treatments, high demand for safe and effective medications, technologies advancements, and increasing prevalence of cancer.

Chronic lymphocytic leukemia is a type of gradually developing leukemia that affects the development of B lymphocytes (also known as B cells). On the other hand, B cells are specialized white blood cells, which produce immunoglobulins (also called antibodies) under normal conditions, and help to protect the human body against infections and diseases. In patients with chronic lymphocytic leukemia, lymphocytes undergo a malignant change and become leukemic cells.

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Ono Pharmaceutical and Bristol-Myers Squibb are in the process of developing Opdivo for the treatment of chronic lymphocytic leukemia. Genentech is developing Atezolizumab, also known as MPDL 3280A, for chronic lymphocytic leukemia therapeutics, which is in Phase II stage. Atezolizumab is a monoclonal antibody targeting programmed cell death-1 ligand 1 (PD-L1). PD-L1 plays an important role in suppressing the immune system triggered by the cancer. PD-L1 acts by reducing the proliferation of antigen-specific CD8+ T-cells and controlling the accumulation of foreign antigen-specific T-cells.

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The chronic lymphocytic leukemia is more prevalent in North America, making the region to be the largest revenue contributor, globally. The U.S. contributed the largest revenue to the North American market in year 2016, and it is expected to remain the largest market across the globe, during the forecast period.

Some of the key players operating in the chronic lymphocytic leukemia therapeutics market are GlaxoSmithKline plc, F. Hoffmann-La Roche AG, Celgene Corporation, Biogen Inc., AbbVie, Inc., Teva Pharmaceuticals Limited, Gilead Sciences, Inc., Novartis AG, and Johnson & Johnson.

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Restless Legs Syndrome Market Performance and Market Share, Sales Revenue and Major Manufacturers Performance, Gross Margin Analysis

Restless legs syndrome or RLS is a neurological disease. RLS is also called as Willis-Ekbom disease. Patients suffering from RLS disease have an irresistible desire to move their feet. The continual movement of the legs leads to pain in the limbs, which leads to the unusual sleep pattern of patients.

The exact reason behind the restless legs syndrome is not known precisely, however, it is believed the disease is caused due to genetic factors or due to iron deficiency in the brain or due to the disorders in dopaminergic balance.

The exact treatment of this disease is not present till now. However the available drug in the market helps in the indicative treatment of the disease. Some of the drug in the restless legs syndrome market such as sulfonamide by safinamide by Newron Pharmaceuticals reduces the symptoms by novel action such as potent, reversible and selective inhibition of MAO-B, without disturbing the MAO-A and dopamine uptake. This enhances the glutamate release and dopaminergic function of the patients; it also reduces the dopamine degradation. One other drug: SER-214 manufacture by Serina is used widely in the restless legs syndrome treatment; it uses a water-soluble polymer poly (2-alkyloxazoline)-based drug delivery technology this drug can be combined with the polymer and transported to the patients.

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Based on the different product type the global restless legs syndrome market can be broadly classified as Mirapex/Sifrol/Mirapexin, Neupro/Leganto, Requip, and HORIZANT/Regnite. On the basis various disease type the global restless legs syndrome market can be broadly bifurcated as etiology and pathogenesis, iron deficiency, genetic factors, neurological disturbances and others. Based on the mode of the therapy the global restless legs syndrome market can be broadly segmented into two broad categories: pharmacological therapy and non-pharmacological therapy.

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Some of the major players operating in the global restless legs syndrome market include, GlaxoSmithKline plc., Ligand Pharmaceuticals Incorporated, axxonis Pharma AG, Kyowa Hakko Kirin Co., Jazz Pharmaceuticals, Inc., Omeros Corporation, Manhattan Pharmaceuticals, Boehringer Ingelheim GmbH, UCB SA.

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Nuclear Medicine (Radiopharmaceuticals) Market by Overview, Growth Opportunities, Manufacturing Cost Structure Analysis, Outlook and Industry Insights Forecast to 2024

The global nuclear medicine/radiopharmaceuticalsmarket is growing significantly due to increasing prevalence of cancer and cardiovascular diseases, and advances in nuclear medicine imaging procedures. High demand of nuclear medicines in emerging economies and potential radiopharmaceuticals in the pipeline create ample opportunities for the nuclear medicine/radiopharmaceuticals market to grow at a considerable rate in the coming years.

The advances in neurological applications and development of new products by the companies are supporting to address the demand for cost effectiveness of radiopharmaceuticals. Nuclear medicine imaging procedures are non-invasive and can be used for the treatment of several diseases, such as cancers, cardiovascular diseases, and neurological disorders.

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The nuclear medicine/radiopharmaceuticals market is segmented on the basis of type, application, and region. On the basis of type, the nuclear medicine/radiopharmaceuticals market can be segmented as diagnostics and therapeutics. The diagnostics segment leads the nuclear medicine/radiopharmaceuticals market. The diagnostics segment can be further categorized into single-photon emission computed tomography (SPECT) and positron emission tomography (PET). SPECT segment will be leading the nuclear medicine/radiopharmaceutical diagnostics market in the coming years due to its wider availability and less cost. The therapeutics segment can be further categorized into beta emitters, alpha emitters, and brachytherapy isotopes. The beta emitters will be the leading segment in the global nuclear medicine/radiopharmaceutical therapeutics market.

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Geographically, North America will be leading the global nuclear medicine/radiopharmaceuticals market in the coming years due to increasing prevalence of cancer, ready availability of radiopharmaceuticals, popularity of nuclear medicine among physicians, and technological advancements.

Asia-Pacific is the fastest growing region in the global nuclear medicine/radiopharmaceuticals market. The major reasons for the fastest growth in the region are increasing healthcare expenditure, and rising awareness of radiopharmaceuticals among healthcare providers. Moreover, Japan will be leading the nuclear medicine/radiopharmaceuticals market in Asia-Pacific region in the coming years.

Some of the major players operating in the global nuclear medicine/radiopharmaceuticals market are GE Healthcare, Bayer Healthcare, Cardinal Health Inc., Eczacibasi-Monrol Nuclear Products, Bracco Imaging S.p.A, Nordion Inc., Lantheus Medical Imaging Inc., Advanced Accelerator Applications S.A, Mallinckrodt plc, and IBA Molecular Imaging.

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Human Growth Hormone Market Share, Strategies, Emerging Technologies, Growth Rate Analysis, Trends and Forecast

The global human growth hormone market is witnessing growth due to the presence of large pool of patients and technological advancements. The increasing compliance for human growth hormone drugs and massive unexplored market in the emerging economies, such as India and China are creating opportunities for the growth of the global human growth hormone market. The advanced research and development facilities, and new drug developments by the key players are propelling the demand for improved and cost effective human growth hormones; further fuelling the growth of the global growth hormone market.

Some of the factors driving the growth of the global human growth hormone market are increasing demand for human growth hormone drugs, increasing incidences of human growth hormone deficiency diseases, growing geriatric population, and technological advancements, such as recombinant DNA technology for the development of human growth hormone drugs. In addition, several major players are investing heavily and collaborating among each other for the research and development of human growth hormone drugs, which is fueling the growth of the global human growth hormone market. However, stringent regulatory approvals, high cost of treatment, and adverse effects associated with the usage of synthetic human growth hormones are some of the factors restraining the growth of the global human growth hormone market to some extent.

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Geographically, North America leads the global human growth hormone market, due to increasing proportion of aged population, high incidences of turner syndrome, short bowel syndrome, human growth hormone deficiency and Noonan syndrome. Moreover, the high demand of human growth hormone drugs as performance enhancer and anti-aging drug in North America is driving the growth of the human growth hormone market in the region. Asia-Pacific is the fastest growing region in the global human growth hormone market, which is driven by increasing healthcare expenditures and high incidences of growth hormone deficiency disorders. Moreover, the human growth hormone market is growing due to increasing disposable income and large geriatric population in the emerging countries, such as India and China.

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Some of the major players operating in the global human growth hormone market are Pfizer Inc., F. Hoffmann-La Roche AG, Novo Nordisk A/S, Merck KGaA, Eli Lilly and Company, Novartis AG, and Teva Pharmaceutical Industries Ltd.

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Global Endometrial Cancer Therapeutics Market - Epidemiology Analysis, Therapy, Development, Growth and Demand Forecast to 2024

Global endometrial cancer therapeutics market is expected to witness significant growth as there are less number of approved drugs for treatment of endometrial cancer, leading to an increased opportunity for the drug manufacturers. High prevalence of cancer and rising demand for safe and effective medications can be attributed as the major drivers of this market. The regulatory bodies such as USFDA and EMA are supporting the growth of the global market by providing increased funding, designations and grants for speeding up the drug development process.

Endometrial cancer is the malignancy that develops in the layers of the cells that forms endometrium, lining of uterus. The precise cause of endometrial cancer is still unknown but it is assumed that estrogen may be involved in developing endometrial cancer, as estrogen helps in the formation of the endometrial lining. Obesity, polycystic ovary syndrome, infrequent periods and history of endometrial polyps can increase the risk of endometrial cancer. Women with diabetes, high blood pressure or breast cancer are at a greater risk of having endometrial cancer. Abnormal vaginal bleeding, bleeding between periods or after menopause, lower abdominal cramps or clear vaginal discharge after menopause are some of the main symptoms of endometrial cancer.

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High prevalence and recurrence of endometrial cancer after treatment with chemotherapy are the major driving factors driving the endometrial cancer therapeutic market.  Growing prevalence of obesity in women aged 50 years or above is also contributing in the growth of the endometrial cancer therapeutics market globally. Apart from this, safety concerns after chemotherapy, hormone therapy and radiation therapy restrict the medications for the treatment of endometrial cancer.

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Geographically, North America is expected to be the largest market for endometrial cancer therapeutics treatment, owing to the large number of research and development activities ad high healthcare expenditure. Europe is expected to hold the second largest share in the global market owing to growing product availability in the region.

Some of the key players operating in the global endometrial cancer therapeutics market are AstraZeneca Plc., Novartis AG, Bristol-Myers Squibb Company, Pfizer, Inc. and R-Pharm-US LLC.

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