Galectins belong to the family of animal lectins and perform
function by interacting with cytoplasmic and nuclear proteins, cell-surface and
extracellular matrix glycoproteins and glycolipids to modulate signalling
pathways. Studies have shown the crucial roles of galectin in cancer as they contribute
to tumour cell survival, tumour metastasis, angiogenesis and neoplastic
transformation.
Many studies have demonstrated role of galectins in the
pathogenesis of various diseases including malignant, fibrotic and inflammatory
diseases; hence, emerges as an attractive target for the therapeutic of various
diseases. Galectin-3 inhibitors has shown positive clinical results for the
treatment of acute lymphoblastic leukemia. Thus, providing several
opportunities to the companies for the development of galectin-based therapies
for the treatment of multiple human diseases.
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The report provides a comprehensive understanding of the
pipeline activities covering all drug candidates under various stages of
development, with detailed analysis of pipeline and clinical trials. Pipeline
analysis of drugs by phases includes product description and development
activities including information about clinical results, designations,
collaborations, licencing, grants, technology and others.
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