The global
protein A resin market is expected to witness considerable growth during the
forecast period due to the increasing research and development activities and
increasing prevalence of chronic diseases. High traction for monoclonal
antibodies in biopharmaceutical industry is supporting the growth of the global
market. The increasing demand for monoclonal antibodies has fueled the need for
high capacity commercial scale purification of monoclonal antibodies.
Protein A
resins are designed for the simple and rapid purification of antibodies.
Therefore, an increase in demand for monoclonal antibodies implies an increase
in demand for protein A resins. The market for natural protein A resin was the
larger than recombinant protein A resin market in 2015; however, recombinant
protein A resin market is expected to witness the higher growth during the
forecast period.
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Protein A,
a 56 kDa surface protein, is found on the cell wall of Staphylococcus aureus
bacterium. The protein has immunoglobulin-binding domains which bind to
proteins, mostly immunoglobulin G (IgG). Protein A binds to the Fc region or
Fab region of immunoglobulins, thus, increasingly being used for immune
precipitation or antibody purification applications. Protein A ligand is used
for the affinity chromatography step in commercial-scale production of
monoclonal antibodies. The key factors driving the use of protein A resin for
antibody purification are high antibody selectivity, increased antibody yield
and excellent antibody purity, and ease of operation in large as well as small
scale antibody purification.
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Geographically,
North America accounted for the largest share in the global protein A resin
market in 2015, owing to the large number of clinical trials for the monoclonal
antibody based therapeutics and increasing traction for biosimilars with the
recent U.S. Food and Drugs Administration in the region. The U.S. contributed
largest revenue to the North American as well as global protein A resin market.
The country is expected to remain the largest market for protein A resin
globally during the forecast period.
The protein
A resin market is expected to witness the highest growth in Asia-Pacific during
the forecast period. The highest growth in the region is attributed to the
increasing compliance for biosimilars and shifting global interest for
expanding biopharmaceutical manufacturing capacities in the emerging economies
of the region.
The key
players operating in the global protein A resin market are General Electric Company, Thermo Fisher Scientific
Inc., Merck KGaA, Tosoh Corporation, Repligen Corporation, Novasep, Expedeon
Ltd., and GenScript.
