Pompe Disease Market - Epidemiology Analysis, Therapy, Growth and Demand Forecast to 2024
Pramod KmrMarch 29, 2019Pompe Disease Market Demand, Pompe Disease Market Growth, Pompe Disease Market Outlook, Pompe Disease Market Share, Pompe Disease Market Size
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The pompe
disease market is growing at a significant rate mainly due to special
provisions for orphan drugs. Regulatory assistance in emerging nations is one
of the major trends seen in the pompe disease market.
Pompe
disease is a type of lysergic acid diethylamide (LSD). LSD refers to a group of
diseases arising from the increase of specific substrates and is inherited
autosomal recessive disorders. Lysergic acid diethylamide is progressive and
having uneven age of onset and clinical symptoms. Pompe disease is a hereditary
and repeatedly incurable disorder caused by lack of acid alpha glucosidase, an
enzyme desired to split down glycogen in particular structures of our body.
Patients
having pompe disease have little amount of or no acid alpha glucosidase enzyme
activity, so break down of glycogen is not possible. The additional glycogen
builds up in the patient and is stored in skeletal muscle, heart and other
tissues, which causes the progressive indications of pompe disease. Increase of
glycogen in certain organs and tissues restraints normal functions of patient’s
organs. Pompe disease is also known by other names such as glycogen storage
disease type II, acid maltase deficiency, lysosomal alpha-glucosidase
deficiency, acid alpha-glucosidase deficiency and glycogenosis type II.
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Pompe disease is categorized into two broad categories as adult-onset pompe disease
and infantile onset pompe disease. Both the parents pass on one strangely
altered copy of the gene to their child. A parent with an altered copy of the
gene is known as a carrier and the disease can affect both men and women
irrespective of the gender. The disease is acquired by the individuals at the
time of birth only, but the onset of indications differs significantly. The
researchers have identified more than 300 genetic mutations that can cause
pompe disease. Enzyme replacement therapy and diet therapy are useful in
dropping the clinical demonstrations of the disease.
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Government
regulations, such as orphan drug exclusivity and limited patient population are
the factors restraining the growth of the pompe disease market.
Some of the
competitors in the market are Genzyme Corporation, EpiVax, Inc., Amicus
Therapeutics, Audentes Therapeutics, BioMarin Pharmaceutical Inc., Valerion
Therapeutics, LLC, Oxyrane, and Sangamo BioSciences Inc.
Pancreatic Cancer Therapeutics Market - Epidemiology Analysis, Therapy, Development, Growth and Demand Forecast to 2024
Pramod KmrMarch 27, 2019Pancreatic Cancer Therapeutics Market Demand, Pancreatic Cancer Therapeutics Market Growth, Pancreatic Cancer Therapeutics Market Share, Pancreatic Cancer Therapeutics Market Size
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The global pancreatic cancer therapeutics market holds numerous
opportunities for the key players, as pancreatic cancer is a highly challenging
disease among all types of cancer, which has no specific treatment available
for it, as of now. Also, growing incidence of cancer and technological
advancements are supporting the growth of the global pancreatic cancer
therapeutics market growth.
Cancer
instigates uncountable growth of cells due to some abnormalities in the body.
Some of the common symptoms of pancreatic cancer include weight loss, diarrhea,
jaundice and abdominal pain. Cancer hampers the pancreas’ normal functioning,
with smoking being the major risk factor for pancreatic cancer. Diagnosis of
this type of cancer is done by patient history check and complete physical
examination, followed by urine, stool and blood tests. Also, personal or family
history of pancreatitis and BRCA2 mutation inclines a person to be affected by
pancreatic cancer.
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In
developing countries, improvement in patient-centered care is being encouraged,
as governments are investing huge amount of funds. Increasing elderly
population base, high prevalence of pancreatic cancer and increase in foreign
investments may be observed, over the forecast period, in the developing
nations such as Asia-Pacific and Middle East Asia.
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The
investment in both segments of pancreatic cancers is significant. However, the
growing prevalence and growing reach of novel techniques in the developing
regions are the aspects likely to drive the growth of the exocrine category,
throughout the forecast period.
Presently,
the global pancreatic cancer therapeutics industry is merged in
nature, with only a few top companies seizing the major share of the market.
Some of the top companies operating in this market are Celgene Corporation; Eli
Lilly and Company; Amgen, Inc.; F. Hoffmann-La Roche AG; PharmaCyte Biotech,
Inc.; Novartis AG; Teva Pharmaceutical Industries Ltd.; Clovis Oncology;
Pfizer, Inc.; and Merck & Co., Inc.
Several
companies are concentrating on the introduction of technologically advanced
products, in order to obtain a significant share in the fast-growing medical
devices area. Also, collaborations, mergers and partnerships with well-established
players are the key approaches followed by top players to increase their market
share, during the forecast period.
Integrated CDSS Segment Expected to Realize Fastest Growth in the Global CDSS Market, During Forecast Period
Vijay KumarMarch 26, 2019CDSS Industry, CDSS Market, CDSS Market Trends, Clinical Decision Support System Market, Global CDSS Market
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The clinical
decision support system market size is expected to cross $1.5 billion by
2022, growing at a CAGR of 21.5% between 2016-2022. The CDSS market is driven
by five major factors, including growing
demand for advanced healthcare information systems, growing investments by HIT
players, growing need for remote patient monitoring services, and increasing
support from government organizations.
The massive unexplored CDSS across the globe has created
abundant opportunities for the major players to exploit the potential of the
CDSS market. Although, there has been significant development in the developed
economies of European Union (EU) and the U.S., the clinical decision support
system market is still at its nascent form, especially in the developing
countries of Asia, Latin America, and Africa. A high growth in numbers of end
user including hospitals, and pharmacy has been witnessed in the developing
countries of these regions, which provides immense growth opportunities for the
CDSS market.
The Asia-Pacific
market for CDSS is expected to grow at a CAGR of 23.2% between 2016-2022. The clinical
decision support system market in
Asia-Pacific is growing, due to growing geriatric population and upsurge in the occurrence rate of different chronic diseases. In
addition, the improving healthcare infrastructure, and favorable government
support, such as investments and grants has fueled the demand of HIT systems
including CDSS in the region. China is expected to grow at a CAGR of 27% during
the forecast period and reach $114.3 million by 2022, in the Asia-Pacific CDSS
market.
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Some of the key companies operating in the CDSS market
include Cerner Corporation, RELX Group PLC, Epic Systems Corporation, General
Electric Company, McKesson Corporation, Zynx Health Incorporated, International
Business Machine Corporation, Siemens AG, Allscripts Healthcare Solutions
Inc., Meditech and Wolters Kluwer.
GLOBAL CDSS MARKET SEGMENTATION
By Product
- Integrated
CDSS Solutions
- Standalone
CDSS Solutions
By Application
- Drug
Dosing Support
- Clinical
Guidelines
- Clinical
Reminders
- Drug-Drug
Interactions
- Drug
Allergy Alerts
- Others
By Model
- Knowledge-based
CDSS Solutions
- Non-Knowledge-Based
CDSS Solutions
By Mode of Delivery
- On-Premises
- Web-Based
- Cloud-Based
By Component
- Software
- Hardware
- Services
By Healthcare Provider Entity Capacity
- Less
than 100 Beds
- 100–199
Beds
- 200–299
Beds
- 300–399
Beds
- 400–499
Beds
- More
than 500 Beds
By Region
- North
America
- U.S.
- Canada
- Rest
of North America
- Western
Europe
- U.K.
- Germany
- France
- Italy
- Spain
- Rest
of Western Europe
- Central
& Eastern Europe
- Russia
- Rest
of Central & Eastern Europe
- Asia-Pacific
- China
- Japan
- India
- Australia
- Rest
of Asia-Pacific
- Latin
America
- Brazil
- Rest
of Latin America
- Middle East and Africa
Source: P&S Intelligence
Pain Management Drugs Market Segmental Analysis by Therapeutics, Diagnostics, Patient, Drugs Policy and Regulatory Landscape
Pramod KmrMarch 07, 2019Pain Management Drugs Market, Pain Management Drugs Market Demand, Pain Management Drugs Market Share, Pain Management Drugs Market Size, Pain Management Drugs Market Trends, Research Report
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The growing
geriatric population and increasing demand of innovative and advanced pain
relaxing medications around the world are the predominant growth drivers for
the global pain
management drugs market. Additionally, the increasing number of
hospitalization cases; unmet requirements for neuropathic pain management
drugs; innovative and advanced applications of pain management therapies;
increasing prevalence of various chronic diseases, such as cancer, and
neurological problems; and increasing healthcare expenditure are also driving
the growth of the global market. The growing numbers of mergers and
acquisitions is a key trend observed in the market. Among the various
therapeutic indications, the post-operative pain relief segment accounted for
the largest share, and the low-back pain segment accounted for the second
largest share in the global market.
Pain
management drugs are mainly used to relieve discomfort associated with injury
and surgeries. Moreover, pain management medications are used in the management
of pain associated with neurological problems, migraine, cancer, orthopedic
problems, low- back pain, rheumatoid arthritis, and fibromyalgia.
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North
America and Europe are the major markets, due to increasing prevalence of
chronic diseases, and growing awareness about various types of chronic pain
conditions in these regions. The U.S. followed by Canada, is the largest market
for pain management drugs in North America. Whereas, the U.K., Germany and
France are some of the major countries holding significant share in the
European pain management drugs market.
The Asian
market is growing with a significant rate, owing to huge pool of patients, and
increasing healthcare spending in the region. In addition, the initiatives
taken by various government associations to develop chronic pain rehabilitation
centers, and increasing prevalence of various chronic diseases are also
supporting the growth of the Asian pain management drugs market. The countries
such as India, Japan and China, are the major markets in the region.
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Apart from
these regions, Latin America is another important market. This is due to
increasing investments by drug manufacturing companies and growing demand of
pain management medications in the region. Brazil holds the largest share in
the Latin American pain management drugs market, due to the increasing support
from government organizations for the development of chronic pain
rehabilitation center in the country.
Some of the
major players operating in the global pain management drugs market include
Purdue Pharma L.P., Teva Pharmaceutical Industries Ltd., Eli Lilly and Company,
Forest Laboratories Inc., Endo International PLC, Johnson & Johnson, Pfizer
Inc., Valeant Pharmaceuticals International Inc., GlaxoSmithKline PLC, F.
Hoffmann-La Roche Ltd., and Baxter International Inc.
Pain
Management Drugs Market Segmentation
By Category
• Prescription-Based Drugs
• Over-The-Counter (OTC) Drugs
By
Therapeutic Indications
• Post-Operative Pain
• Low-Back Pain
• Rheumatoid Arthritis Pain
• Osteoarthritis Pain
• Cancer Pain
• Migraine
• Neuropathic Pain
• Fibromyalgia
• Others
By Brands
• Maxalt
• Zomig
• Qutenza
• Lidoderm
• Savella
• Imitrex
• Voltaren Gel
• Celebrex
• Cymbalta
• Others
By
Geography
• North America
o U.S.
o Canada
• Europe
o Germany
o France
o U.K.
o Spain
o Italy
• Asia
o Japan
o China
o India
• Latin America
o Brazil
• Rest of the World
Neuroendocrine Carcinoma Therapeutics Market Outlook, Growth Opportunities, Major Competitors and Porter Analysis
Pramod KmrMarch 05, 2019Neuroendocrine Carcinoma Therapeutics Market, Neuroendocrine Carcinoma Therapeutics Market Demand, Neuroendocrine Carcinoma Therapeutics Market Share, Neuroendocrine Carcinoma Therapeutics Market Size
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Global neuroendocrine
carcinoma therapeutics market is witnessing significant growth due to large
number of marketed drugs and Phase III drugs. Neuroendocrine carcinoma is a
tumor that begins in neuroendocrine cells and can spread, or metastasize, to
other parts of the body. It starts in the hormone producing cells of the body’s
neuroendocrine system. Neuroendocrine tumors can begin in many organs
including, lungs, brain and gastrointestinal tract. It is a very rare cancer
with symptoms such as hyperglycemia, hypoglycemia, diarrhea, weight loss, pain,
cough, lump formation, jaundice, unusual bleeding, headache and anxiety. The
risk factors of developing neuroendocrine cancer includes, age, gender, family
history, immune system suppression, arsenic exposure and sun exposure. The
diagnosis can be done by normal physical examination followed by blood tests,
urine tests, X- ray, CT scan, PET scan, MRI and biopsy.
The
treatments available for neuroendocrine tumor include chemotherapy, surgery and
radiation therapy. Chemotherapy comprises the drug’s use to destroy malignant
cells by hindering the cells ability to divide and grow. Streptozocin (Zanosar)
and 5-fluorouracil (Adrucil, 5-FU) are some of the drugs that are used to treat
neuroendocrine tumors. Many pharmaceutical companies have been working
continuously for the development of targeted therapy for the growth of
neuroendocrine cancer market.
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Sunitinib
(Sutent) and Everolimus (Afinitor) are two major targeted drugs that are being
used for treatment of neuroendocrine cancer. Genentech Inc., F. Hoffmann-La
Roche Ltd., Callisto Pharmaceuticals Pvt. Ltd. and BioSynthema, Inc. are some
major companies that are determined to develop therapeutics for various
neuroendocrine cancers. Lutathera, Atiprimod and Avastin are pipeline
candidates that are presently being studied for their therapeutic efficacy in
the treatment of neuroendocrine cancer. Also, there are many other pipeline
drugs in Phase III which are expected to enter the neuroendocrine carcinoma
therapeutics market in the future.
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Geographically,
neuroendocrine carcinoma therapeutics market has been segmented into North
America, Europe, Asia Pacific and Rest of the World (RoW). According to
Cancer.Net, approximately 8,000 people are identified with neuroendocrine cancer
every year in the U.S. Several key players functioning in neuroendocrine
carcinoma therapeutics market are based in the U.S and therefore consider North
America as their main market for product launch and research and development
investments. Also, entrenched infrastructure and favorable reimbursement
scenario are the major factors accountable for the strengthening of North
America’s neuroendocrine carcinoma therapeutics market. Europe is the second
largest market for neuroendocrine carcinoma therapeutics, followed by Asia.
Increasing prevalence of neuroendocrine cancer in Asia Pacific along with the
refining economic scenario is expected to play an important role in driving the
market growth in the region.
Some of the
key players operating in the global
neuroendocrine carcinoma therapeutics market include Pfizer Ltd., Eli
Lilly & Company, Novartis AG, F. Hoffmann-La Roche Ltd., Ispen SA, Amgen,
Inc., Teva Pharmaceuticals, Ltd. and Bristol-Myers Squibb among others.
Opioid Induced Constipation Market Analysis, Demand, Growth Opportunities and Recent Trends by Leading Manufacturers and Regions
Pramod KmrMarch 01, 2019Induced Constipation Market, Induced Constipation Market Demand, Induced Constipation Market Growth, Induced Constipation Market Share, Induced Constipation Market Size, Trends
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Opioids are
directed to the patients suffering from the acute and chronic non-cancer pain.
The opioids have numerous adverse intestinal effects, such as opioid-induced
constipation. The opioids also affect the discharge of digestive enzymes that
can sometime cause partial gastro paresis. Some of the most familiar symptoms
of opioid-induced constipation includes, hard and dry stools, swelling, painful
defecation, distention and protruded abdomen, tiredness, and loss of hunger.
Some of the most common opioid-induced constipation therapy is the use of
targeted therapies, OTC and off-label drugs and changing lifestyle.
On the
basis of different form of drug the global opioid-induced constipation market
can be bifurcated into two broad categories: solid and liquid. Some of the
dominant market drivers for opioid-induced constipation includes, rising number
of OIC patients, and widespread use of opioids treatment in chronic non-cancer
pain. The current opioid-induced constipation market is led by the inexpensive
and widely available laxatives. The clinical efficiency of laxatives is poor
compared to its counterparts; however they still broadly used in constipation
relief.
Lack of
awareness about the opioid-induced constipation in patients, and the doctors
are one of the dominant causes of off-label and OIC medications as majorly used
treatment methods. However, the efficiency of these drugs is only the half of
some of the other therapies. The entrance of superficially acting mu-opioid
receptor rivals such as Movantikv or Moventig are driving the opioid-induced
constipation market. Movantikv or Moventig drug targets only the fundamental
reason of opioid-induced constipation without affecting the effect of the
opioid drugs.
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Europe was
the largest market of the opioid-induced constipation market in 2015 in terms
of value. It is then followed by North America. The market dominance of Europe
is attributed the presence of a large number of baby boomers population in the
region. North America was the fastest growing market for opioid-induced
constipation in 2014, the market size of North America is expected to surpass
the Europe during the forecast period. The high growth of the market is
attributed to the supportive government incentive in healthcare services in
addition with the presence of a large pool of patients suffering from chronic
pain.
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In
September 2014 the U.S. Food and Drug Administration (FDA) has approved methyl
naltrexone bromide hypodermic injection, 12 mg/0.6ml, for the treatment of
opioid-induced constipation for the patients using opioids non-cancer chronic
pain. This approval from the FDA is expected to serve approx. 11 million
patients in the U.S. who are suffering from opioid-induced constipation.
Based on
the different form of therapy the global opioid-induced constipation market can
be broadly categorized as non-tamper resistant formulations (non-TRFs) and
tamper resistant formulations (TRF). The non-TRFs has the largest market share
in 2014, however the TRFs is expected to more dominant treatment technology in
upcoming years attributed mainly to the U.S. Food and Drug Administration (FDA)
promotions and broad pipeline of oral
(TRFs) approval.
Some of the
major players operating in the global
opioid-induced constipation market include, AstraZeneca plc, Valeant
Pharmaceuticals International Inc., Takeda Pharmaceutical Co. Ltd., Salix
Pharmaceuticals, Ltd., Progenics Pharmaceuticals, Inc., Abbott Laborites, and
Bayer AG among others.
Glaucoma Therapeutics Market Demand, Developments, Industry Opportunities and Industry Research Report
Pramod KmrMarch 01, 2019Demand, Glaucoma Therapeutics Market, Glaucoma Therapeutics Market Growth, Glaucoma Therapeutics Market Share, Glaucoma Therapeutics Market Size, Outlook, Research Report
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Glaucoma is
a disease of eye which is caused by excessive increase of fluid pressure within
the eye. Glaucoma is caused due to mechanical compression or decreased blood
flow in the optic nerve of the patient’s eye. If not treated properly, it may
lead to mild loss of vision and even blindness. Treatment of glaucoma includes
laser therapies, pharmaceutical drugs and surgical procedures.
Ocular
hypertension is one of the major causes due to which glaucoma occurs in
patients. Glaucoma mostly occurs at the age over 40, but it may also occur in
children, young adults, and infants. Diagnosis of glaucoma can be done through
a simple eye examination with the help of tonometry, an instrument used for
measuring intraocular pressure, by an ophthalmologists and optometrist.
Prevention of glaucoma is difficult; however, if diagnosed and treated at an
early stage, the disease can be controlled by using eye drops prescribed by
doctor, microsurgery or by laser surgery. Glaucoma can damage the vision of the
affected eye permanently; in first stage it decreases the peripheral vision and
if not treated, it can lead to blindness.
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Some of the
major factors driving the growth of glaucoma therapeutics market are aging
population of developed countries, development of advanced glaucoma drug
delivery devices and rising global healthcare expenditures. Stringent
government regulation and marketing approval, side effects of glaucoma
medications and long development process of the glaucoma products are some of
the major factors restraining the growth of global glaucoma therapeutics
market.
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North
America was the largest glaucoma therapeutics market in 2014, attributed to
high per capita expenditure on healthcare in this region. It is followed by
Europe and Asia-Pacific. Asia-Pacific region is also the fastest growing
glaucoma therapeutics market, owing to the aging population of Japan coupled
with the increasing healthcare expenditure of developing countries, such as
India and China. Asia-Pacific glaucoma therapeutics market is further expected
to witness growth and surpass North America market in terms of largest market during
the coming years.
Some of the
major competitors in global glaucoma therapeutics market are Pfizer Inc.,
Allergen Inc., Novartis A.G., Merck & Co. Inc., Aerie Pharmaceuticals Inc.,
Inotek Pharmaceuticals Corp., Carl Zeiss Meditec Inc., Acadia Pharmaceuticals
Inc., Neurotech Pharmaceuticals Inc., NicOx SA, Santen Pharmaceuticals Co.
Ltd., Otsuka Holdings Co. Ltd., SIFI SpA, and Valeant Pharmaceuticals
International Inc.
Testicular Cancer Therapeutics Market - Epidemiology Analysis, Therapy, Development, Growth and Demand
Pramod KmrMarch 01, 2019Growth, Outlook, Research Report, Testicular Cancer Therapeutics Market, Testicular Cancer Therapeutics Market Demand, Testicular Cancer Therapeutics Market Share, Testicular Cancer Therapeutics Market Size
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Global
testicular cancer therapeutics market is growing with the increasing prevalence
of testicular cancer. The market is expected to witness moderate growth, since
there are already more than 15 drugs that exist in the market for the treatment
of testicular cancer. Increasing prevalence of cancer and rising demand for the
medications with better efficacy and less side effects can be attributed as an
opportunity for oncology. The regulatory bodies such as USFDA, EMA are
supporting the growth of the global market by providing increased funding,
designations and grants for speeding up the drug development process.
Testicular
cancer is the tumor that develops in the testicles. Testicles are the glands
found in men that produce testosterone hormone and sperms. The cause of
testicular cancer is attributable to enormous growth of testicular cells due to
some abnormalities, resulting in the formation of tumor in testicles, causing
testicular cancer. Cryptorchidism, inguinal hernia, congenital abnormalities,
abnormal testicular development and family history can increase the risk of
testicular cancer. Mumps orchitis are also one of risk factors which is a very
rare complication of mumps, which involves the inflammation of testicles. Pain,
swelling, discomfort, sensation of heaviness and sudden fluid accumulation in
scrotum are the main symptoms of testicular cancer.
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Growing
prevalence of testicular cancer and combination therapies for the treatment are
the major driving forces for the testicular cancer therapeutics market. Also
with no drug in Phase III, there is a need for growth in pipeline for better
treatment options, providing increased opportunities to the players in the
market. Some of the marketed drugs for the treatment of testicular cancer
include Blenoxane (Bleomycin), Cisplatin, Cosmegen (Dactinomycin), Cyfos
(Ifosfamide), Etopophos (Etoposide Phosphate) and Velban (Vinblastine Sulfate).
Some of the drug combination available in the market are BEP, JEB, PEB, VIP and
VeIP.
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The
treatment is more effective if the chemotherapy regimen involves two or more
drugs rather than using any single drug. Therefore, chemotherapy is expected to
have major share in the global testicular cancer therapeutics market.
Some of the
key players operating in the global
testicular cancer therapeutics market are Ovation Pharmaceuticals,
Inc., ZIOPHARM Oncology Inc., Bristol-Myers Squibb Company, Hospira Inc., Teva
Pharmaceutical Industries Ltd., Fresenius Kabi AG and Teva Parenteral
Medicines, Inc.