Cathepsin K is a protease enzyme which is coded by CTSK gene. The function associated with the gene involves bone remodelling and resorption. Cathepsin K is a member of peptidase C1 protein family and expressed mainly in osteoclasts. The protein has high specificity for kinins and has the capability to catabolize collagen, elastin, and gelatin. Cathepsin K is found to be over-expressed in cancer such as breast cancer and glioblastoma. The mutation in CTSK gene can cause pycnodysostosis. Due to over expression of cathepsin K in osteoclasts, bone deformation occurs which leads to osteoporosis.
Company like Medivir AB is in the process of developing MIV-711 as a cathepsin K inhibitor for the treatment of osteoarthritis. Amura Holdings Ltd., and Merck & Co. Inc. are some other companies having pipeline of cathepsin K inhibitors.
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The report provides a comprehensive understanding of the pipeline activities covering all drug candidates under various stages of development, with the detailed analysis of pipeline and clinical trials. Pipeline analysis of drugs by phases includes product description and development activities including information about clinical results, designations, collaborations, licensing, grants, technology, and others.
Cannabis can be divided based on various factors. Generally, this flower produces a yellow or brown sticky substance when trimmed classified as indica, hybrid, or Sativa, based on the structure and form of the plants. But cannabis can further be classified through an informal definition by the culture, such as Purple, Haze, and Kush. These terms refer to the kinds of cannabis characterized by effects, flavors, geographic regions, and smell. The name Kush applies to a wide variety of cannabis strains originating from the Hindu Kush region. Kush strains may be pure landrace strains that are indigenous to this area or potent hybrids that are bred with the addition of Kush genetics. Kush believed to have appeared in public for the first time in the US in the 1970s. Kush genetics is also the spine of many new hybrids on the market, such as OG Kush, Purple Afghan Kush, Hindu Kush, Critical Kush, and kushmart.for more info visit:
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