Aurora
kinase are proteins that function as mitotic regulators and are
aberrantly expressed in cancerous cells. Aurora kinase inhibitors target these
aberrantly expressed regulators, provides genetic stability and prevents
tumorigenesis.
Several studies have demonstrated overexpression and
amplification of aurora kinase in various haematological and solid cancers.
Aurora kinase inhibitors when combined with other anti-cancer agents gives more
positive results in variety of cancers. Better evaluation of aurora kinase
inhibitors is required which raises the need of biomarkers, effective and novel
therapeutic agents. Also, aurora kinase inhibitors selectivity targets cancer
cells rather than healthy tissues, providing potential opportunities for more
effective drug development with reduced adverse effects.
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AstraZeneca PLC is in the process of developing AZD-2811 as
a small molecule which acts as an aurora B inhibitor for the treatment of solid
tumors. Some of the other companies having pipeline of aurora kinase inhibitors
include AbbVie Inc., Merck & Co., Inc., and CASI Pharmaceuticals Inc.
The report provides a comprehensive understanding of the
pipeline activities covering all drug candidates under various stages of
development, with detailed analysis of pipeline and clinical trials. Pipeline
analysis of drugs by phases includes product description and development
activities including information about clinical results, designations,
collaborations, licencing, grants, technology and others.
Cannabis can be divided based on various factors. Generally, this flower produces a yellow or brown sticky substance when trimmed classified as indica, hybrid, or Sativa, based on the structure and form of the plants. But cannabis can further be classified through an informal definition by the culture, such as Purple, Haze, and Kush. These terms refer to the kinds of cannabis characterized by effects, flavors, geographic regions, and smell. The name Kush applies to a wide variety of cannabis strains originating from the Hindu Kush region. Kush strains may be pure landrace strains that are indigenous to this area or potent hybrids that are bred with the addition of Kush genetics. Kush believed to have appeared in public for the first time in the US in the 1970s. Kush genetics is also the spine of many new hybrids on the market, such as OG Kush, Purple Afghan Kush, Hindu Kush, Critical Kush, and kushmart.for more info visit:
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